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Možnosti produkce a využití medicínského konopí na českém trhu
Kristen, Alan
This diploma thesis deals with the issue of medical cannabis treatment in the Czech Republic. The first part of the thesis discusses cannabis from the point of view of history, taxonomy, where the cannabis plant is described, and morphology, where the main active substances contained in cannabis are defined and described. The objective of the analytical part of the work was to evaluate the development of the medical cannabis commodity vertical and to compare the results with the situation in the State of Israel. The thesis chronologically shows the process of making medical cannabis available to patients in the Czech Republic and Israel, including legislative developments in both countries. The evaluation of the development of the vertical was carried out on basis of the collection of selected statistical data of individual countries during the past years, and subsequently a graphic comparison was created to determine the difference in the approaches to cannabis treatment of the two mentioned states. In the conclusion, the development of the production and consumption of medical cannabis in the Czech Republic is evaluated in comparison with the situation in the State of Israel.
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Medical cannabis in the Czech Republic from the point of view of doctors- qualitative study
Čabanová, Aneta ; Šejvl, Jaroslav (advisor) ; Jandáč, Tomáš (referee)
Background: Since 2010, medical professionals have been working to make cannabis available for medical use. In 2013 enter into force a public notice, which provides conditions for the handling of cannabis for medical use. In 2019 came into force a law, which regulates conditions for prescribing and reimbursing cannabis for medical use. In 2022 came into force an amendment of this law with minor changes. Aims: The aim of the bachelor is to map the situation regarding the prescribing of cannabis for medical use in the Czech Republic. The aim is also to describe the history of cannabis as a medicine, the therapeutic effects of substances contained in cannabis, the methods of applying cannabis and the legislation and competence of doctors regarding prescribing too. The aim is to find out whether the effects that are described in the literature are the same in practice. Methods: A qualitative study using a semi-structured interview was used for data collection. The respondents in the research became doctors who are authorized to prescribe medical cannabis and also actively prescribe it. The interview was recorded on a dictaphone and subsequently transcribed into MS Word. The transcripts were then analyzed using the bunching method. Results: The administration of cannabis for therapeutic use to patients...
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Lék nebo hrozba? Antropologické perspektivy samoléčby konopím v České republice
Bláhová, Barbora ; Horák, Miroslav (advisor) ; Halbich, Marek (referee)
This diploma thesis focuses specifically on the phenomenon of self-medication with cannabis (Cannabis Sativa L.) in the Czech Republic exploring subjective perception of this treatment by ill persons and its sociocultural framework. It describes a situation when the state fails to effectively regulate medical cannabis and patients often seek practices of self-medication, which remains illegal. Theoretical part of this thesis aims to explain the self- medication and cannabis use in the sociocultural context. Practical part is based on an anthropological research, which was implemented in the Czech Republic from January 1, 2017 to May 1, 2017 in a form of the on-line qualitative questionnaire survey. The research sample consists of 107 subjects, who used cannabis and its derives for self-medication. The analysis was done by the Grounded theory method. The results demonstrate that people who seek cannabis self-medication in the Czech Republic consider current legal regulation of cannabis objectionable. Cannabis plants for self-medication are usually grown at home and people find information about specifics of the treatment on-line. Looking at experience of patients, this thesis describes specifics of the practices of cannabis self-medication and it could be useful for organizations working with...
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Vplyv vonkajších faktorov na produkciu sekundárnych metabolitov u rodu konope
Bartoš, Jakub
This bachalor work was focused on external factors and their effect on plants secondary metabolic products. Theoretical section is dedicated on morphological and botanical charakteristic and history of cannabis plant. In section is also information from medical and research field from effect area of cannabis. Work discuss the most important secondary metabolites, their signal pathways, centres and meaning for plants and humankind. Practical section is dedicated on external effect of nutrients and environment on final product. The aim of this experiment was compare effect of anorganic fertilizers vs organic fertilizers. The biggest yield of flowers were from nutient group with weight 17.87 grams. The biggest CBD concentration was in organic group with 11.3 % and the biggest THC concetration was in control group 0.446 %. We could observe differences between groups in height, field or metabolites concetration but it wasn´t statistically conclusiv
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Lék nebo hrozba? Antropologické perspektivy samoléčby konopím v České republice
Bláhová, Barbora ; Horák, Miroslav (advisor) ; Halbich, Marek (referee)
This diploma thesis focuses specifically on the phenomenon of self-medication with cannabis (Cannabis Sativa L.) in the Czech Republic exploring subjective perception of this treatment by ill persons and its sociocultural framework. It describes a situation when the state fails to effectively regulate medical cannabis and patients often seek practices of self-medication, which remains illegal. Theoretical part of this thesis aims to explain the self- medication and cannabis use in the sociocultural context. Practical part is based on an anthropological research, which was implemented in the Czech Republic from January 1, 2017 to May 1, 2017 in a form of the on-line qualitative questionnaire survey. The research sample consists of 107 subjects, who used cannabis and its derives for self-medication. The analysis was done by the Grounded theory method. The results demonstrate that people who seek cannabis self-medication in the Czech Republic consider current legal regulation of cannabis objectionable. Cannabis plants for self-medication are usually grown at home and people find information about specifics of the treatment on-line. Looking at experience of patients, this thesis describes specifics of the practices of cannabis self-medication and it could be useful for organizations working with...
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Antimicrobial aktivity of cannabis extract in pathogens causing skin disease
Pařízek, Štěpán ; Fraňková, Adéla (advisor) ; Klouček, Pavel (referee)
Diseases caused by microbes are worldwide cause of morbidity and public health risks. Despite undisputed global benefits of antibiotics, the occurrence of infections caused by antibiotics-resistant bacteria becomes more frequent. This can be attributed to increased consumption of antibiotics in the long term, but also to their inappropriate use. Appart from that, progress in the field of synthetic antibacterial drugs research is dramatically stagnating in recent decades, plus the the antibiotics have bad effects to many bacteria types beneficial to human body. This generates a strong need to seek for natural remedies with similar or better antimicrobial effects. It is known that many plants produce a wide range of secondary metabolites with antimicrobial effects. Such metabilites inhibit growth and reproduction of pathogenic microorganisms by various mechanisms. From explored herbal medicines hemp, traditionally used to cure many diseases, appears to be a suitable alternative to antibiotics.
This thesis focuses on the antimicrobial activity of extracts of six different cannabis genotypes. Extracts with different ratios of cannabinoids have been tested using in vitro microdilution method on selected pathogens, causing skin disease (Staphylococcus spp., Streptococcus spp.).
Results confirmed the antimicrobial activity of all tested extracts. Very good minimum inhibitory concentration was assessed mainly for Streptococcus spp. with a concentration of 4 ug/ml. Extracts NHS4, JB3 and CK3 showed best results against all pathogens, with minimal inhibitory concentrations in the range from 4 to 16 ug/ml. Only extracts of CK2, N3 and JC1 have proven ineffective (MIC 512 ug/ml), because they could not be evaluated by the inhibitory concentration.
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Cultivation of Cannabis (Cannabis sativa L. C. indica L) and the Use of Its’ Biologically Active Substances in Medicine
Kahánková, Zdeňka ; Hamouz, Karel (advisor) ; Božik, Matěj (referee)
Cannabis has been used as a medicine throughout the history. For the first time the therapeutic use of cannabis was documented in China, 4000 B.C.
The cannabis plants contain significant levels of biologically active secondary metabolites, such as cannabinoids, enzymes, glycoproteins, alcohols, aldehydes, ketones, simple acids, fatty acids, steroids, terpenes, phenols, flavonoids, vitamins, pigments, etc. Attention has been focused particularly on the cannabinoid expressing the psychoactive effects tetrahydrocannabinol (THC). Concentration of this substance in the plant represents the difference between therapeutic and technical cannabis; technical cannabis has 0,3 % of THC and less.
The concentration of the secondary metabolites in the different stages of the life of the plant is strongly influenced by the external factors present during the cultivation. Due to this fact it is necessary to cultivate medical cannabis indoors, under strictly controlled cultivation conditions. Respecting the standardized conditions is key in order to fulfil the limits necessary for its following use in therapy and/or research.
The discovery of the cannabinoid receptors meant a breakthrough as it allowed the scientists to explain the effect of cannabis on specific tissues. An intense research of the synthetic ligands of cannabinoid receptors has been ongoing currently. Phytocannabinoids, terpenes and other secondary metabolites of cannabis express synergistic actions, meaning they should not be examined separately, but rather be considered a complex.
It can be assumed that the cannabinoid therapy will become a golden standard, which will help reduce the symptoms of the disease and even cure the patient.
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Selection of cannabis chemotypes suitable for therapeutic use with predominant active substance THC
Michnová, Lenka ; Fraňková, Adéla (advisor) ; Klouček, Pavel (referee)
During recent years the possible medical application of cannabis has been discussed more and more. It turns out, that the active substances (cannabinoids cannabidiol and tetrahydrocannabinol) have a significant potential in medicine and do not have to be only misused as a recreational drug. The Department of Crop Production (Faculty of Agrobiology, Food and Natural Resources) is the first institution with granted permission to legally cultivate cannabis, with higher THC content than 0,3 %, for research purposes.
The first part of literate review recapitulates the basic knowledge about the cannabis, its biologically active substances and current legislation. The second part describes the endocannabinoid system and utilization of cannabis in the field of medicine. This thesis aims to evaluate the THC and CBD content in seven different cannabis cultivar strains (Nurse Jackie, Conspiracy Kush, Jillybean, Jack Cleaner 2, Jack Skellington, Nordle and National Health Service). The cannabis plants were cultivated in three cultivation cycles. The content of active substances in dried and homogenised inflorescence was analysed by gas chromatography with flame ionization detection (GC-FID) according to UN methodology. Based on the analysis, the appropriate genotypes were chosen, which are in accordance of Regulation 236/2015 Sb. and needs of the patients.
According to results it was found, that all seven analysed cultivars are suitable for medical utilization regarding the content of THC and CBD. The highest average content of THC was measured by cultivar Jack Cleaner 2. On the other hand, the lowest THC content was established by cultivar Nordle. It was demonstrated, that the differences in THC content are connected rather to genotype variation than cultivation factors. The main goal of the thesis was to discover which of the seven cultivars will be stable regarding not only THC and CBD content, but also the crop yield. In those regards the research shows the cultivar Jack Cleaner 2 and Nurse Jackie as the most suitable. Preliminary results indicate that these two cultivar strains would be the most suitable for the therapeutic purposes.
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